英文原著

Reactive oxygen species up-regulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells.

Uchida T, Sakashita Y, Kitahata K, Yamashita Y, Tomida C, Kimori Y, Komatsu A, Hirasaka K, Ohno A, Nakao R, Higashitani A, Higashibata A, Ishioka N, Shimazu T, Kobayashi T, Okumura Y, Choi I, Oarada M, Mills EM, Teshima-Kondo S, Takeda S, Tanaka E, Tanaka K, Sokabe M, Nikawa T.

Am J Physiol Cell Physiol. 2018 in press.

PMID: 29513566

 

VEGF pathway-targeting drugs induce evasive adaptation by activation of neuropilin-1/cMet in colon cancer cells.

Tomida C, Yamagishi N, Nagano H, Uchida T, Ohno A, Hirasaka K, Nikawa T, Teshima-Kondo S.

Int J Oncol. 2018 Apr;52(4):1350-1362. doi: 10.3892/ijo.2018.4291. Epub 2018 Feb 28.

 

Distinct gene expression profile distinguishes increased metabolic activity in spontaneously

hyperactive rats while sedentary from that induced by exercise.

Abe M, Matsuo Y, Harada-Sukeno A, Uchida T, Kitahata K, Tomida C, Hirasaka K, Teshima-Kondo S, Harada N, Nakaya Y, Sakaue H, Nakao R, Nikawa T

Advances in Biological Chemistry 2018 in press.

 

 

 

和文総説、日本語著書

[Update on recent progress in vitamin D research. Vitamin D and muscle tissues.]

Kaneko I, Miyamoto KI, Nikawa T.

Clin Calcium. 2017;27(11):1571-1578. doi: CliCa171115711578. Japanese.

PMID: 29074829

 

 

英文原著、総説

Co-Administration of Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein Increases Masseter Muscle Mass and Fiber Size.

Bayarsaikhan O, Kawai N, Mori H, Kinouchi N, Nikawa T, Tanaka E.

J Nutr Sci Vitaminol (Tokyo). 2017;63(4):244-248. doi: 10.3177/jnsv.63.244.

PMID: 28978871

 

Regorafenib induces adaptive resistance of colorectal cancer cells via inhibition of vascular endothelial growth factor receptor.

Tomida C, Nagano H, Yamagishi N, Uchida T, Ohno A, Hirasaka K, Nikawa T, Teshima-Kondo S.

J Med Invest. 2017;64(3.4):262-265. doi: 10.2152/jmi.64.262.

PMID: 28954993 

 

Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder.

Umehara H, Numata S, Watanabe SY, Hatakeyama Y, Kinoshita M, Tomioka Y, Nakahara K, Nikawa T, Ohmori T.

Sci Rep. 2017;7(1):4855. 

PMID: 28687801

 

Antiangiogenic agent sunitinib induces epithelial to mesenchymal transition and accelerates motility of colorectal cancer cells.

Tomida C, Yamagishi N, Nagano H, Uchida T, Ohno A, Hirasaka K, Nikawa T, Teshima-Kondo S.

J Med Invest. 2017;64(3.4):250-254. doi: 10.2152/jmi.64.250.

PMID: 28954991 

 

Nutritional counseling regulates interdialytic weight gain and blood pressure in outpatients receiving maintenance hemodialysis.

Sakai A, Hamada H, Hara K, Mori K, Uchida T, Mizuguchi T, Minaguchi J, Shima K, Kawashima S, Hamada Y, Nikawa T.

J Med Invest. 2017;64(1.2):129-135. 

PMID: 28373609

 

 

Involvement of Cbl-b-mediated macrophage inactivation in insulin resistance.

Abe T, Hirasaka K, Nikawa T.

World J Diabetes. 2017;8(3):97-103. 

PMID: 28344752  

 

Development and performance evaluation of a three-dimensional clinostat synchronized heavy-ion irradiation system.

Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, Takahashi A.

Life Sci Space Res (Amst). 2017;12:51-60. 

PMID: 28212708

 

 

Metabolic Suppression by 3-Iodothyronamine Induced Muscle Cell Atrophy via Activation of FoxO-Proteasome Signaling and Downregulation of Akt1-S6K Signaling.

Ju H, Kim T, Chung CM, Park J, Nikawa T, Park K, Choi I.

Biol Pharm Bull. 2017;40(5):576-582. 

PMID: 28163294 

 

 

Modulation of cutaneous extracellular collagen contraction by phosphorylation status of p130Cas.

Takeya M, Okumura Y, Nikawa T.

J Physiol Sci. 2017;67(5):613-622. 

PMID: 27718170

 

 

 

和文総説、日本語著書

Plasticity of skeletal muscle against unloading stress.

Kishimoto H, Uchida T, Kitahata K, Nikawa T.

Clin Calcium. 2017;27(3):351-356. 

 

PMID: 28232649

 

Impacts of physical exercise on remodeling and hypertrophy of skeletal muscle.

Sakashita Y, Uchida T, Nikawa T.

Clin Calcium. 2017;27(1):79-85. 

 

PMID: 28017949

 

 

8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice.

Mukai R, Horikawa H, Lin PY, Tsukumo N, Nikawa T, Kawamura T, Nemoto H, Terao J.

Am J Physiol Regul Integr Comp Physiol. 2016;311(6):R1022-R1031. 

PMID: 27629889

 

 

 

Preventive effect of dietary quercetin on disuse muscle atrophy by targeting mitochondria in denervated mice.

Mukai R, Matsui N, Fujikura Y, Matsumoto N, Hou DX, Kanzaki N, Shibata H, Horikawa M, Iwasa K, Hirasaka K, Nikawa T, Terao J.

J Nutr Biochem. 2016;31:67-76. 

PMID: 27133425

 

 

Capric Acid Up-Regulates UCP3 Expression without PDK4 Induction in Mouse C2C12 Myotubes.

Abe T, Hirasaka K, Kohno S, Tomida C, Haruna M, Uchida T, Ohno A, Oarada M, Teshima-Kondo S, Okumura Y, Choi I, Aoyama T, Terao J, Nikawa T.

J Nutr Sci Vitaminol (Tokyo). 2016;62(1):32-9. 

PMID: 27117849

 

UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion.

Hirasaka K, Mills EM, Haruna M, Bando A, Ikeda C, Abe T, Kohno S, Nowinski SM, Lago CU, Akagi K, Tochio H, Ohno A, Teshima-Kondo S, Okumura Y, Nikawa T.

Biochem Biophys Res Commun. 2016;472(1):108-13. 

PMID: 26915802

 

Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin.

Ohno A, Ochi A, Maita N, Ueji T, Bando A, Nakao R, Hirasaka K, Abe T, Teshima-Kondo S, Nemoto H, Okumura Y, Higashibata A, Yano S, Tochio H, Nikawa T.

Arch Biochem Biophys. 2016;594:1-7. 

PMID: 26874193

 

 

 

 

The malignant progression effects of regorafenib in human colon cancer cells.

Tomida C, Aibara K, Yamagishi N, Yano C, Nagano H, Abe T, Ohno A, Hirasaka K, Nikawa T, Teshima-Kondo S.

J Med Invest. 2015;62(3-4):195-8.

PMID: 26399347

 

Effects of dietary soy protein on skeletal muscle volume and strength in humans with various physical activities.

Hashimoto R, Sakai A, Murayama M, Ochi A, Abe T, Hirasaka K, Ohno A, Teshima-Kondo S, Yanagawa H, Yasui N, Inatsugi M, Doi D, Takeda M, Mukai R, Terao J, Nikawa T.

J Med Invest. 2015;62(3-4):177-83. 

PMID: 26399344

 

Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis.

Nowinski SM, Solmonson A, Rundhaug JE, Rho O, Cho J, Lago CU, Riley CL, Lee S, Kohno S, Dao CK, Nikawa T, Bratton SB, Wright CW, Fischer SM, DiGiovanni J, Mills EM.

Nat Commun. 2015;6:8137. 

PMID: 26310111

 

Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes.

Shiota C, Abe T, Kawai N, Ohno A, Teshima-Kondo S, Mori H, Terao J, Tanaka E, Nikawa T.

J Nutr Sci Vitaminol (Tokyo). 2015;61(2):188-94. 

PMID: 26052151 

 

A novel myogenic function residing in the 5' non-coding region of Insulin receptor substrate-1 (Irs-1) transcript.

Nagano H, Yamagishi N, Tomida C, Yano C, Aibara K, Kohno S, Abe T, Ohno A, Hirasaka K, Okumura Y, Mills EM, Nikawa T, Teshima-Kondo S.

BMC Cell Biol. 2015;16:8. 

PMID: 25887310

 

 

Refeeding with glucose rather than fructose elicits greater hepatic inflammatory gene expression in mice.

Oarada M, Takahashi-Nakaguchi A, Abe T, Nikawa T, Miki T, Gonoi T.

Nutrition. 2015;31(5):757-65. 

PMID: 25837224

 

Chronic exposure of VEGF inhibitors promotes the malignant phenotype of colorectal cancer cells.

Tomida C, Yamagishi N, Aibara K, Yano C, Uchida T, Abe T, Ohno A, Hirasaka K, Nikawa T, Teshima-Kondo S.

J Med Invest. 2015;62(1-2):75-9. 

PMID: 25817288

 

N-myristoylated ubiquitin ligase Cbl-b inhibitor prevents on glucocorticoid-induced atrophy in mouse skeletal muscle.

Ochi A, Abe T, Nakao R, Yamamoto Y, Kitahata K, Takagi M, Hirasaka K, Ohno A, Teshima-Kondo S, Taesik G, Choi I, Kawamura T, Nemoto H, Mukai R, Terao J, Nikawa T.

Arch Biochem Biophys. 2015;570:23-31.

PMID: 25689493

 

 

Prevention of skeletal muscle atrophy in vitro using anti-ubiquitination oligopeptide carried by atelocollagen.

Kawai N, Hirasaka K, Maeda T, Haruna M, Shiota C, Ochi A, Abe T, Kohno S, Ohno A, Teshima-Kondo S, Mori H, Tanaka E, Nikawa T.

Biochim Biophys Acta. 2015;1853(5):873-80. 

PMID: 25667084

 

 

Osteoactivin attenuates skeletal muscle fibrosis after distraction osteogenesis by promoting extracellular matrix degradation/remodeling.

Tonogai I, Takahashi M, Yukata K, Sato R, Nikawa T, Yasui N, Sairyo K.

J Pediatr Orthop B. 2015;24(2):162-9. 

PMID: 25405936